Environmental or self-antigens and homotypic interactions trigger BCR and Toll-like receptor (TLR) signaling, amplifying the response of CLL cells to other indicators from your microenvironment and expanding the activation of anti-apoptotic and proliferation pathways.31,32 Genomic studies have determined recurrent mutations in genes regulating tumor cell-microenvironment interactions,... https://orlandox853pwe9.cosmicwiki.com/user