Pentobarbital will decrease the level or effect of prednisone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. pentobarbital will decrease the level or effect of vincristine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown. pentobarbital will decrease the level or effect of exemestane by affecting hepatic/intestinal enz... https://socialinplace.com/story5757335/esamina-la-relazione-sulla-pentobarbital-vs-phenobarbital